ABSTRACT
Introduction: Pathologies of hair growth can be psychologically distressing but they are poorly controlled. Hormones and paracrine factors regulate the hair follicle and its associated glands. However, our understanding of their mechanisms is limited, restricting the development of new treatments for hair disorders. Therefore better treatments for hair loss disorders are required. Some plant extracts are believed to have effect on hair growth. Urtica Cannabina L and other are used traditionally as stimulators of human hair growth, but their effects on hair growth in vivo has not been studied yet. Goal: The aim of this study was to investigate the actual effects of those local plant extracts used as a traditional herbal treatment for hair loss, using in vivo mouse model; and to compare their effectiveness with the best medical treatment available. Material and methods: Effects of extracts from Urtica Cannabina L, and Glycyrrhiza uralensis Fisch both prepared separately and mixed at recommended concentrations. Experimental groups were compared with standard (positive control) and negative control groups. Shaved back of Balb/c mice (4 weeks old) were treated daily for 28 days (four groups, n=6 per group), and degree of their effectiveness was observed and compared with each other and with both of positive and negative control. Results: show that mixture of the two herbal extract have similar significant hair growth promotion effect compared with other groups and negative control. Therefore, extracts stimulates rodent pelage follicles in vivo, thus possible to use as promoter of hair growth. Keywords: Urtica Cannabina L, Glycyrrhiza uralensis Fisch, hair follicle, hair loss, mice.
ABSTRACT
Wistar nonlinear rats weighing 170-220g. Rats were divided 5 groups, including control group, group-1, group-2, group -3 and reference group. Dried thistle extract and raw bovine testicle were contained by 1:1, 1:2 and 2:1 ratio. Each 0.1g ratio was dissolved in 20 ml distilled water and administered 2 times per day. Blood sampling was done for each rat after 3, 7, 14, 21, 28 and 35 days. Their testosterone level was measured by ELISA Kit. Results: The results indicated that free serum testosterone level in male rats increase and decrease in 7 days frequency. All tested groups showed gradual increase in the level of free serum testosterone when compared to that of corresponding control (p<0.05). Statistical comparison of all groups revealed that the maximum level was found in group 1. Moreover, group 3 was showed gradually increase in level of free serum testosterone, irrelative with period of decrease testosterone level. Conclusion: According to our results and previous study, it is suggested that preparation with Tribulus terrestris L. extract could be used in the androgen deficiency and erectile dysfunctions. Keywords: Tribulus Terrestris L, Free testosterone, Dihydrotestosterone, Protodioscin
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Background Soft-form medicine means types of medicines that are characterized by a thick, paste-like consistency in their external features and that are used for external application and treatment as soft-form ointments, creams, etc. These types of medicines included forms such as unguentum, pasta, suppositorium, emplastrum, linimentum, creme and gel. With our previous research, we demonstrated that in the medical and pharamaceutical market of Mongolia, there are 7 national manufacturers that produce 16 kinds of unguentum and soft-form medicine. In this research we made a content analysis, using the coded list of imported soft-form medicines that were registered in Mongolia as of 2014 and indicated the possibilities for production of these medicine by national manufacturers.
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Introduction: The present study shows the processing of the pharmacopoeia article for the preparation of Di- clofenac sodium extended release matrix tablet formulated from alternative characteristic poly- mer. The matrix tablets were prepared according to traditional method of the wet granula- tion for tablet form medicine. Method: A standardization study made use of several international pharmacopoeias, such as the Mongolian National Pharmacopoeia (MNP 2011), United States Pharmacopoe- ia (USP 32), Chinese Pharmacopoeia (CP 2010) and U.S Department of F.D.A for the sub- stance’s requirements. Result: The results from this study showed a completely processed manufacturing pharma- copoeia issue of the Diclomon 100 mg retard tablet and its technological and standardized re- quirements.
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"Helicobacter pylori (H.pylori) is considered an etiologic factor for the development of peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The combination of a proton pump inhibitor and two antibiotics has been the recommended first line therapy since the first guidelines for Helicobacter pylori infection in patients were published. However, bacterial resistance and adverse events occurrence are among most frequent causes for anti H.pylori treatment failure. More effective anti H.pylori therapy have been investigated in depth by researchers. One of the potential therapies is probiotic cultures; promising results have been observed in initial studies with numerous probiotic strains. Most of studies showed an improvement of H.pylori gastritis and decreasein H.pylori colonization after administration of probiotics. However, utilization of probiotics alone is not able to complete eradication H.pylori infection as published. The combination of some probiotic strains with standard triple therapy can reduce the occurrence of side effect due to antibiotics and increase the H.pylori eradication rate. In this article, we reviewed the possible mechanisms of action of probiotics on H.pylori and results of published studies using probiotics as possible agents to eradicate"
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Abstract: Since the ancient times Mongolian traditional medicine widely used a sheep’s fat tail. As sheep fat tail oil is natural originated pure product, which has high concentration of unsaturated acid and valuable treatment and nutritional efficiency, this study was conducted to identify the possibility to use sheep fat tail oil instead of cosmetic raw material. We prepared bodylotion, bodycream and bodybutter base from sheep fat tail and determined “pH” MNS 1474:2000, “Acid number” MNS 1131:2000, “Heat stability” MNS 4961:2000 and microbiological analysis. From our results it is shown that cosmetic products, meets the standard requirements. Key words: sheep fat tail, cosmetic products
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Introduction: Normal human body temperature generation increase by called fever. Various disease syndrome symptoms of fever and high temperature ( 38.50C or more ) reduce the short term, especially when young children cerebral glucose deficiency epileptic disease is beginning fall, and brain tissues and cell malnutrition become parallel, paralysis, as a result of Poor memory and create the risk. Therefore, The World Health Organization (WHO) according 0-3 month infants 380C more than, 3-6 months 38.50C, and 6 months - 1 year old children body temperature 390C more than they must to use medicine or called to doctor. Infants and young children’s drug therapy is recommended for use in practice “ParaDenk 125mg, ParaDenk 250mg”, Panadol suspension (contain 120 mg paracetamol), Nurofen (contain Ibuprofen100mg) syrup. Irritation and fever, all the scenes prostoglandin much as synthesized. The main of this ibuprofen’s mechanism is inhibit prostoglandin synthesized. Domestic pharmaceutical market the ibuprofen containing Nurofen 100 ml suspension drugs are widely used in the treatment of young children, but the cost is high. The scope of research and ibuprofen suspension technologies pharmaceuticals manufacturer has been developed pharmacopeias article. The main aim of this study was to perform quality determination of “Ibumon 100mg /5 ml” 100 ml suspension. Material and methods: We studied “Ibumon” suspension technological and tandardization research in Drug experiment and manufacturer sector in Drug Research Institute. We prepared “Ibumon” suspention by Nurofen suspension’s drug registration according to the physical characteristics of materials. The appearance and suryp’s physical and chemical method determined by in the Mongolian national pharmacopeia. The microbial limit test in the Mongolian National Pharmacopeia was performed to determine microbial purity. Suspension’s Ibufrofen content determined by HPLC equipment . Result: “Ibuprofen” suspension pharmaceutical technology research as effective ingredients have been determined. And the suspension active ingredient quantitative analysis determined by HPLC.
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Introduction: The World Health Organization (WHO) according respiratory allergic diseases, nasal mucosal disease , which is one factor to create asthma and more than 300 million people become infected is accured in 2012[1]. In 2012, acconding to statistics of the Ministry of Health for our country was noted of 5% of the total population of the allergic disease and astma.Also In 2000, the prevalence of astma among the population was 2.4%, but in 2010 increased by 4.8%. Accordingly , the prevalence of the disease is increasing year by year, that’s why the imported new drug’s of diseases in the market and the need to produce domestically. Domestic market, we used allergic rhinitis, mucosal inflammatory treatment cholorphenamine 4 mg (Monos Industry LLC), Tavegil (Novartis Russia ), ketotifen (So pharma, Bulgaria), letizine 10 mg (KRKa, Slovani), Cetirizine 10 mg (Bertecs pharma, Russian). Letizine 10 mg, Cetirizine 10 mg drugs are contain of Ceterizine dicholoride, widely used in the treatment of foreign drug. Divided in the medical treatment of children aged 2-6 years , these drugs are expected to give a child , so we import the drug entering the appropriate doses of the company with the goal to obtain. For that purpose we determination allergon tablet’s technological process. Conclusion: Technological experiment “Alergon 5 mg ” tablets were selected ingredients of ceterizine dihydrocholoride 0.005 g, glucose monohydrate 0.09444 g, K-30 0.00006 g, magnesium stearat 0.0005 g. According to our study, ”Allergon 5 mg” tablets average weight, weigth range, disintegration, hardness, assay meets the standards set in the Mongolian National Pharmacopeia requirement of “Tablet drug ”.